Inflammatory Activity in Patients with Obstructive and Non-obstructive Coronary Artery Disease

Aim . To study the levels of pro-inflammatory biomarkers in patients with obstructive and non-obstructive coronary artery disease (CAD), to identify possible differences for diagnosing degree obstruction. Material methods The observational included two groups patients: (main group, stenosis <50%; n=30) (comparison hemodynamically significant according results angiography; CAD. interleukin-1β (IL-1β) interleukin 6 (IL-6) were measured plasma using enzyme immunoassay. Results IL-6 significantly higher CAD (p=0.006) than There no level IL-1β both (p=0.482). When constructing ROC curve, threshold value was 26.060 pg/ml. At less this value, diagnosed insignificant stenoses arteries. Conclusion confirm that different types lesions, there are activity inflammation process arterial wall. lesion did not differ between groups. Thus, it can be assumed obstruction arteries develops as a result highly active vascular Given presence proven biological basis available data on effectiveness monoclonal antibodies IL-1β, one cannot exclude their benefit cohort stenoses.